منابع مشابه
Radical-free biology of oxidative stress.
Free radical-induced macromolecular damage has been studied extensively as a mechanism of oxidative stress, but large-scale intervention trials with free radical scavenging antioxidant supplements show little benefit in humans. The present review summarizes data supporting a complementary hypothesis for oxidative stress in disease that can occur without free radicals. This hypothesis, which is ...
متن کاملAlcohol, Oxidative Stress, and Free Radical Damage
Reactive oxygen species (ROS) are small, highly reactive, oxygen-containing molecules that are naturally generated in small amounts during the body's metabolic reactions and can react with and damage complex cellular molecules such as fats, proteins, or DNA. Alcohol promotes the generation of ROS and/or interferes with the body's normal defense mechanisms against these compounds through numerou...
متن کاملPhloroglucinol Attenuates Free Radical-induced Oxidative Stress
The protective role of phloroglucinol against oxidative stress and stress-induced premature senescence (SIPS) was investigated in vitro and in cell culture. Phloroglucinol had strong and concentration-dependent radical scavenging effects against nitric oxide (NO), superoxide anions (O2 (-)), and hydroxyl radicals. In this study, free radical generators were used to induce oxidative stress in LL...
متن کاملpeptide-associated free radical oxidative stress
Amyloid b-peptide (Ab), the central constituent of senile plaques in Alzheimer’s disease (AD) brain, has been shown to be a source of free radical oxidative stress that may lead to neurodegeneration. In the current study Ab(1-40), found in AD brain, and the amyloid fragment Ab(25-35) were used in conjunction with electron paramagnetic resonance spin trapping techniques to demonstrate that these...
متن کاملAlcohol, oxidative stress and free radical damage.
The involvement of free radical mechanisms in the pathogenesis of alcoholic liver disease (ALD) is demonstrated by the detection of lipid peroxidation markers in the liver and the serum of patients with alcoholism, as well as by experiments in alcohol-feed rodents that show a relationship between alcohol-induced oxidative stress and the development of liver pathology. Ethanol-induced oxidative ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2008
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00283.2008